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C., Chao, A

Summary GLP-1 agonists are effective for weight loss and can help maintain weight loss while in use

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Derived from the proglucagon gene, oxyntomodulin acts as a dual agonist at GLP-1 and glucagon receptors, promoting satiety and increasing energy expenditure (Cohen et al., 2003)

The bio-availability of the DPP-4 inhibitors is very good and the pharmacodynamic- as well as the pharmacokinetic characteristics lead to the above mentioned clinically sufficient DPP-4 inhibition with once daily dosing (only vildagliptin has to be dosed twice daily) (18, 19)

There is also a reassuring reduction in the incidence of several cancers, including pancreatic