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According to Darji, people using GLP-1s may experience nausea, vomiting and constipation

doi: 10.1007/s13679-017-0262-y 8 LincoffAMBrown-FrandsenKColhounHMDeanfieldJEmersonSSEsbjergSet al

However, a published expert review of the Phase 2 data in Expert Opinion on Investigational Drugs (2023) noted: "Heart rate was increased by up to 6.7 beats/min by retatrutide, which may be detrimental and offset some of the benefits of weight loss" particularly for patients with cardiovascular comorbidities

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These are being reported directly by patients, recorded by frontline care providers and pharmacists, fed back by drug sales teams, and captured as part of patient support programs (PSPs)