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Prednisolone promotes insulin resistance, hepatic glucose production, and fat synthesis, which exacerbate fatty liver No evidence supports corticosteroids as treatment for non-alcoholic fatty liver disease (NAFLD) Lifestyle modification, particularly 710% weight loss, remains the cornerstone of fatty liver management Patients requiring prednisolone for other conditions need careful monitoring of weight, glucose, lipids, and liver function Never stop prescribed corticosteroids abruptly due to risk of serious adrenal insufficiency Table of Contents What Is Fatty Liver Disease and How Is It Treated
At steady state, single deviations such as a missed or double dose, a dose with shorter (15 min) or longer (120 min) post-dose fasting time or a dose taken with a larger volume of water (240 mL) will result in only minor and transient changes in exposure