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GLP-1RAs can cross the bloodbrain barrier and activate brain GLP-1 receptors, leading to neuroprotection by improving insulin signaling, reducing tau hyperphosphorylation, and enhancing cognitive function in diabetic and aging models

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Functional neuroimaging studies complement these structural findings by highlighting disrupted connectivity patterns in individuals with T2DM

Central nervous pathways of insulin action in the control of metabolism and food intake

explored the chondroprotective effects of olive leaf extract rich in OLE, finding that the extracts supplementation prevented cartilage degeneration in mice with knee osteoarthritis, potentially by modulating hyaluronan metabolism in synovial cells [101]

Bone is extraordinarily dynamic