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Il meccanismo d'azione sulla perdita di peso Il calo di peso avviene soprattutto perch questi farmaci aiutano a ridurre lintroito calorico : aumentano la saziet, diminuiscono la fame e rendono pi facile rispettare un piano alimentare ipocalorico

PKA directly phosphorylates sulfonylurea receptor 1 (SUR1), a regulatory subunit of voltage-dependent K + channels and KATP channels, increasing membrane depolarization and voltage-gated Ca 2+ channel activation

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From a pharmacokinetic perspective, besides increased gastric emptying, obesity has been suggested to modulate CYP gene expression, and increased fat mass may result in an increased Vd of lipophilic drugs.210,211 The weight loss effects from GLP-1 RA treatment may reverse these changes and alter the pharmacokinetics of co-administered lipophilic drugs by decreasing the Vd (Figure 3)