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This comprehensive research timeline provides substantial evidence regarding efficacy, safety, and cardiovascular benefits across diverse patient populations, making semaglutide one of the most thoroughly studied medications in its class

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However, our understanding of the function of GLP-1RAs is not complete, and further research, including long-term and large clinical trials are warranted to properly evaluate the causal relationship between GLP-1RAs and the development and progression of various cancers

doi: 10.1007/s40618-017-0799-3
