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The pre-specified primary efficacy analyses included data from study 1 and pooled data from studies 2 and 3, regardless of glycemic rescue or treatment discontinuation

Results : Our NMA of 29 RCTs with 145,895 participants found that only two exendin-4 derivativeslixisenatide and high-dose efpeglenatide (i.e., 6 mg/week)showed increased hearing loss events compared to controls

doi: 10.1161/CIRCRESAHA.111.300233 150 LiCReifMMCraigeSMKantSKeaneyJF

The GLP1 journey: from discovery science to therapeutic successes. JCI
