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Side effects Common side effects include dizziness, drowsiness, and fatigue

The SURPASS-5 study assessed the efficacy and safety of an injectable combination therapy combining tirzepatide with insulin glargine (75)

Additionally, patients experiencing significant nausea may eat less frequently or consume smaller portions, potentially leading to inadequate caloric intake or skipped meals, both of which are well-established headache triggers

The study measured weight loss at two points: 24 weeks and 48 weeks

Conversely, rapid weight loss may pause temporarily during high-stress periods or with inconsistent injection timing

Impact of the gut microbiota on the development of obesity: current concepts