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Reduction in Inflammation and Cardiovascular Risk: GLP-1 medications may: Reduce pro-inflammatory cytokines Improve microvascular function Positively influence the gut microbiome Support gut health and digestion Help balance hormones Emerging research suggests potential benefits for conditions such as: Rheumatoid arthritis Psoriasis Hormone Balance Polycystic ovarian syndrome (PCOS) These effects may help lower the risk of chronic diseases including heart disease, fatty liver disease, kidney disease, and autoimmune conditions

(3) Lack of Early Indicators- prior to the cardiovascular outcomes trials (CVOTs), there was no strong evidence or clear biological indicators suggesting that this class of drug would have a direct effect on cardiovascular health

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Understanding GLP-1s for Diabetes, Weight Loss, and Beyond Mayo Clinic: Lets Talk Low Libido Arillotta D et al

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