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Acknowledgments The authors thank the Welch Foundation (Grant AT-1595), American Diabetes Association (Grant 7-07-JF-02), National Institutes of Health (Grant 1 R56 DK080128-01A1), and Juvenile Diabetes Research Foundation (Grant 37-2011-20) for their financial support

(When taking Zepbound to treat sleep apnea, the maintenance doses are 10 mg or 15 mg.) In between those doses are transition doses of 7.5 mg and 12.5 mg weekly

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Therefore, we expect to achieve the same efficacy and side effects as the injectable treatment

268 The latter includes both central homeostatic (energy-intake-focused) and non-homeostatic (reward-focused) regulation of food consumption in the hypothalamus and nucleus of the solitary tract, 268-271 influenced by a relatively small amount of GLP-1 that crosses the blood-brain barrier and, more notably, GLP-1 modulation of vagal afferent neurons