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However, during prolonged stimulation, -arrestin-2 exerts a desensitizing influence, promoting receptor down-regulation and lysosomal targeting, thereby reducing long-term responsiveness

Women of reproductive age are particularly vulnerable

Pigs were kept at a 12/12 h lightdark cycle separated by a 1530 min dusk period

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1,2 By specifically binding to the key hormone GLP-1, it regulates blood glucose levels and lipid metabolism