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By David Prince, MD | Montefiore Medical Center Although new GLP-1 agonist weight loss drugs such as Ozempic, Wegovy, Trulicity, and Byetta are currently dominating the headlines, the majority of overweight Americans may not qualify for these medications due to limited availability and insurance plan restrictions

The answer is yes, and this combination is often used to improve blood sugar control more than either medication could alone.

Since tirzepatide is a dual GLP1R/GIPR agonist, the interpretation is compelling: GIP receptor activation normally buffers the nausea-inducing effects of GLP-1 agonism, and when that buffer is genetically impaired, the GLP-1 component goes unchecked

Payers are known to vary their level of control between different indications for the same drug and between different payer channels, and the GLP-1 market is no exception

Key players in Chiles GLP-1 segment: Novo Nordisk Market leader with Ozempic, Victoza, and Wegovy Eli Lilly Bringing innovation with Mounjaro (Tirzepatide) Sanofi Providing Soliqua, a GLP-1 + insulin combo CFR Pharmaceuticals (Abbott) Local affiliate with strong market access Biocon Expanding biosimilar reach in Latam AstraZeneca Strategic focus on metabolic & cardiovascular synergy With increasing physician adoption and patient demand, Chile is evolving into a high-opportunity market for obesity and type 2 diabetes therapies