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The study by Elkind-Hirsch et al

Recently, genome editing therapies have predominantly targeted diseases with well-defined causative mutations, which affect only about 0.5% to 1% of the global population

There are case reports, clinical anecdotes, and small series, but no large, long-term randomized trials specifically testing microdosing schedules

Empagliflozin may not be suitable for everyone, especially those with certain health conditions

These data suggest a potential for long-term benefit of liraglutide treatment in many patients, as weight loss of 515% has been shown to improve obesity-related complications including diabetes and cardiovascular disease risk factors [5, 9, 59]

In the phase II program, tirzepatide was also shown to improve biomarkers for cardiovascular risk and to improve NASH (6365)