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PMCID: PMC8717485

effective contraception is recommended for women of childbearing potential Individuals with renal impairment : whilst no routine dose adjustment is required for the class, there is an increased risk of dehydration and acute kidney injury from gastrointestinal side effects, and monitoring is advised Individuals with hepatic impairment : limited data are available

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2 CKD confirmatory secondary endpoints Significant 18% RRR of MACE with Ozempic 2 For adults with T2D and CKD, for a confirmatory secondary endpoint: Time to first occurrence of MACE (CV death, nonfatal MI, or nonfatal stroke) vs placebo when both were added to standard of care 1,2 Time to first MACE 1-3,w-z 1-3,w-z w Cumulative incidence estimates are based on time from randomization to first EAC-confirmed MACE with non-CV death modelled as a competing risk using the Aalen-Johnson estimator