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CHF congestive heart failure, LVEF left ventricular ejection fraction, HbA1c glycated hemoglobin, HF heart failure, T2DM type 2 diabetes mellitus, MI myocardial infarction, Afib atrial fibrillation, GLP-1RAs GLP-1 receptor agonists, HR hazard ratio, CI confidence interval However, Arturi et al

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Formulated with the absorption enhancer sodium N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC), oral semaglutide undergoes direct mucosal exposure in the stomach ( Supporting this concept, a recent preclinical study demonstrated that chronic exposure to the absorption enhancer SNAC significantly altered gut microbial community structure, reduced the abundance of saccharolytic bacteria and fecal butyrate levels, and was associated with changes in inflammatory markers, suggesting that components of the oral formulation itself may influence hostmicrobiome interactions independently of systemic GLP-1 receptor activation ( Crucially, the expanding landscape of incretin mimetics requires a clear distinction between standard mono-agonists and next-generation or multi-agonist formulations

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Semaglutide for weight loss: unanswered questions