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Metabolic phenotyping of GLP-1MK-801 After the dose-determination studies (Extended Data Fig

Evidence indicates that GLP-1RAs preserve mitochondrial function by enhancing calcium uptake, improving membrane potential, increasing ATP production, promoting mitochondrial biogenesis, and reducing oxidative stress and apoptosis (172,173)

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People who combine regular exercise with dietary improvements often experience better appetite suppression than those relying on diet alone

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A study reported that insulin-resistant (IR) mice, induced by a high-oil, high-sugar diet followed by streptozotocin (STZ), were treated with GP at doses of 1.25, 2.5, and 5.0 g/kgbw for five weeks