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In microglia, GLP-1R activation via PI3K/Akt signaling also reduces neuroinflammation by modulating NF-B activity, decreases the production of pro-inflammatory cytokines, increases anti-inflammatory markers such as IL-10, IL-4, Arginase, and CD206, and the transformation of microglia into an anti-inflammatory state
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This suggests roughly one-quarter (25%) of the total weight lost was lean mass
19 Additionally, the increased hip, abdominal and scrotal adiposity contributes to impaired thermoregulation of the testes, further compromising spermatogenesis
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He is a board-certified clinical specialist in both orthopedic physical therapy and sports physical therapy and is a fellow of the American College of Healthcare Executives
