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Second, we did not account for some residual confounding even after adjusting potential confounders in our analyses

FDA approves first oral GLP-1 treatment for type 2 diabetes. September 20, 2019

Know that the insulin component creates hypoglycemia risk while the GLP-1 component causes gastrointestinal effects
It is important to note that these data were obtained using a surrogate molecule and may not be directly extrapolated to the clinical candidate, Maridebart Cafraglutide (MariTide)

More serious but rare side effects include: Pancreatitis (inflammation of the pancreas) Gallbladder problems Changes in heart rate While these serious complications are uncommon, they underscore why these drugs require medical supervision
The addition of tirzepatide to insulin glargine was evaluated in the SURPASS-5 study, focusing on patients with T2DM who had inadequate glycemic control
