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Nat Rev Nephrol 13:605 Skov J (2014) Effects of GLP-1 in the Kidney

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Notably, caloric restriction (CR) and moderate weight loss (approximately 510%) improve insulin sensitivity despite the accompanying loss of muscle mass, and the observed reduction appears to result primarily from increased proteolysis rather than reduced protein synthesis

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Furthermore, GLP-1 RAs exhibit neuroprotective properties observed in models of neurodegenerative diseases, including Alzheimers and Parkinsons, which may extend to the treatment of psychiatric conditions [26,79]