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Inflammatory Responses: Semaglutide may trigger mild inflammatory responses, potentially leading to muscle or joint pain

In terms of changes in fat mass, the decreases in right arm, left arm, android, and gynoid were all greater than those in the right leg and left leg, a difference that may be related to variations in baseline fat mass across regions

Each of these weight loss medications possesses distinct advantages and considerations, making it essential to delve into their mechanisms of action, efficacy, method of administration, potential side effects, and cost to make a well-informed decision

6 Semaglutide mimics incretin hormones, enhancing insulin secretion, delaying gastric emptying, and suppressing appetite, leading to approximately 12% weight loss in clinical trials

Missing data were imputed using available data according to value and timing of last available observation on treatment and endpoints baseline value from retrieved subjects (RD-MI)