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Graphical Abstract Similar content being viewed by others Opinion Statement In treating obesity within the context of heart failure (HF), an individualized approach is important
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It may be suitable for you to use long-term if you are finding it to be effective and you do not experience any severe or ongoing side effects
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An exon trapping assay confirmed that this variant causes skipping of exon 2, which is predicted to result in a frameshift (p.Ser2Ilefs*13), consistent with complete loss of protein function
Human evidence - Phase 2 NEJM (Jastreboff et al., 2023) 338 adults with obesity but no diabetes
