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Description
The beneficial effect of TZT in T2DM and obesity is related to direct activation of GIP and GLP-1 receptors with subsequent improvement of insulin sensitivity and reduction of body weight

If side effects are severe or significantly affecting your quality of life, your physician can adjust your dosing schedule, slow the dose escalation, recommend dietary changes, or explore alternative treatment options

Standard practice includes: Baseline thyroid function tests (TSH and free T4) before initiating GLP-1 therapy Repeat testing at 812 weeks after starting treatment or after dose escalation Regular monitoring every 36 months during active weight loss Return to annual monitoring once weight is stable and thyroid function remains consistent Adjustments to levothyroxine dosing may be necessary as weight changes

June 21, 2021

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Glickman notes
