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Additionally, the risk of hospitalization for heart failure with GLP-1 RA therapy in participants receiving and not receiving SGLT2 inhibitors at baseline was similar (HR 0.58

For patients with sensitive skin or a history of allergic reactions, discussing pre-treatment with oral antihistamines with their healthcare provider may be appropriate

Weight consistently rebounded after cessation of GLP-1RAs

Values presented as percentage of total Adverse events are presented for all participants who were randomised and took at least one dose of treatment, regardless of whether they discontinued * For the T2D trial, this was limited to supraventricular arrhythmias and cardiac conduction disorders ** For the obesity trial these are presented as hepatic disorder / biliary disorder separately NA : Not applicable In the obesity trial, serious adverse events (SAEs) occurred in 4% of participants with retatrutide use overall (06% across groups) vs

Noguchi T, Katoh H, Nomura S, Okada K, Watanabe M (2024) The GLP-1 receptor agonist exenatide improves recovery from spinal cord injury by inducing macrophage polarization toward the M2 phenotype