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The majority of circulating biologically active GLP-1 in man is the GLP-1 (7-36) amide form, with lesser amounts of the bioactive GLP-1 (7-37) form also detectable (Orskov et al., 1994)

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These findings reveal a novel mechanism underlying the protective effects of GLP-1RA in diabetes management and highlight PPAR and UCP2 as potential therapeutic targets for diabetes

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