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doi: 10.3389/fendo.2021.721135 32 Simental-MendaLESnchez-GarcaALinden-TorresESimental-MendaM

Vaduganathan M, Docherty KF, Claggett BL, Jhund PS, de Boer RA, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, et al

GIP is known to stimulate insulin secretion in response to macronutrients

compounded versions are not FDA-approved but use the same active ingredients

Orforglipron A promising oral non-peptide GLP-1RA showing: Significant HbA1c reduction Double-digit weight loss Improved convenience Potential global accessibility This may dramatically expand the use of GLP-1 therapy worldwide

If that question is relevant for you, this article on how some patients find calm with Adderall explains why stimulant response can feel calming in one person and uncomfortable in another