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STEP 1 (Wilding et al., 2021, New England Journal of Medicine) enrolled 1,961 participants and demonstrated a mean body weight reduction of 14.9% at 68 weeks with 2.4mg subcutaneous semaglutide, the first pharmacological intervention to produce weight loss of this magnitude in a Phase 3 trial, establishing a new efficacy benchmark that became the comparison standard for all subsequent metabolic compounds including Tirzepatide and Retatrutide

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Rybelsus es un medicamento de administracin oral que pertenece al grupo de los agonistas del receptor del pptido similar al glucagn tipo 1 (GLP-1)