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MariTide (AMG 133 / maridebart cafraglutide) is Amgens investigational, first-in-class bispecific molecule that combines GLP-1 receptor agonism with GIP-receptor antagonism using a peptide-antibody conjugate

2022;5(9):e2232584

64.Qysmia

Receptors are proteins that sit in the membrane of cells and bind a specific molecule

GLP-1 receptor agonists, the drug class that includes semaglutide (sold as Ozempic and Wegovy), appear to reduce cravings, lower overdose risk and decrease substance use disorder diagnoses in real-world studies
