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Conclusions GLP-1RAs have emerged as transformative therapies in T2D and obesity, but their impact may extend beyond metabolic regulation into the realm of immune modulation

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the 2022 Summary of Modifications and Explanatory Notes

Both GLP-1s and exercise can have significant, but somewhat different, impacts on cardiovascular health

Ex-4 significantly reduces neuroinflammation by converting proinflammatory M1 microglia into anti-inflammatory M2 microglia both in vitro and in vivo through the rescue of the expression of Arf and Rho GAP adapter protein 3 (ARAP3)

For state Medicaid agencies that opt to participate in the model, implementation will be on a rolling basis from May 1, 2026 through January 1, 2027