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This implies that DPP4is, characterized by their small molecular size (below 500 Da), can effectively hinder the enzyme's catalytic site, inhibiting its function, while preserving the molecule's capacity to act as a costimulatory factor without disruption
Uehara, Y
Additionally, coffee influences the secretion of gastrointestinal peptides such as glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP), lowering glucose absorption in the small intestine [41,42], and activating central anorexigenic peptides (POMC/CART) as well as inhibiting orexigenic peptides (AgRP/NPY) [43,44]
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Warren M
[DOI] [PubMed] [Google Scholar] 41.Leipold G, Tth R, Hrsfalvi P, Lczi L, Trk M, Keszthelyi A, et al
