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These NMR data are in line with ligand-bound GLP-1R ECD crystal structures showing that the GLP-1 is a kinked but continuous -helix (Thr 13 Val 33 ), whereas the truncated exendin 939 is a straighter helix (Leu 10 -Lys 27 ) than GLP-1 when bound to GLP-1R (Runge et al., 2008

Alters SE, McLaughlin B, Spink B, Lachinyan T, Wang CW, Podust V, Schellenberger V, Stemmer WPC (2012) GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohns disease model

Sokos GG, Bolukoglu H, German J, Hentosz T, Magovern GJ, Maher TD, Dean DA, Bailey SH, Marrone G, Benckart DH, Elahi D, Shannon RP: Effect of glucagon-like peptide-1 (GLP-1) on glycemic control and left ventricular function in patients undergoing coronary artery bypass grafting

The first GLP-1 drug entered the market for the treatment of Type 2 diabetes, with Ozempic following in 2017 and Mounjaro in 2022

New studies show that using these hormones as supplements could lead to good ways to handle weight management and problems with metabolism