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Additionally, the appetite suppression that makes these medications effective for weight management may inadvertently reduce overall fluid intake, as patients often consume less food and beverages throughout the day

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EXSCEL, exenatide study of cardiovascular event lowering trial

1 For patients who do not achieve their target A1C with metformin, the Diabetes Canada 2018 guidelines recommend selecting add-on therapy based on individual patient characteristics

Preclinical studies have indicated that GLP1RAs, such as tirzepatide, may directly impact the vasculature by enhancing endothelial function and decreasing inflammation, which are important in preventing atherosclerosis[30]

Novo already operates large plants in Denmark and in Clayton for insulin
