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2 The two dominant incretins are glucagon-like peptide-1 (GLP-1), secreted by enteroendocrine L cells (located in the ileum and colon), and glucose-dependent insulinotropic peptide (GIP), secreted by K cells (located mainly in the duodenum)

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In the UK, the diagnostic pathway typically involves initial assessment in primary care, often including faecal calprotectin testing to distinguish inflammatory from non-inflammatory bowel conditions