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A recent review concludes that ghrelin and GLP-1 also show opposing effects on food reward-associated behaviors in rodent and humans (Decarie-Spain & Kanoski, 2021)
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The profound anatomical and pathophysiological disparities between these models and human disease create a significant translational gap. Acknowledging these limitations is key to interpreting preclinical data cautiously and designing more relevant experimental paradigms
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[DOI] [PubMed] [Google Scholar] 291.Michelotti GA, Machado MV, Diehl AM
