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This dual approach is particularly beneficial for CKD patients with mild to moderate impairment who require more intensive metabolic support

Cerebrovascular outcome or events consisted of ischemic stroke (ischemia, ischemic stroke, vertebrobasilar insufficiency, cerebrovascular insufficiency, and lacunar infarction) or TIA (including reversible ischemic neurologic deficit), hemorrhagic stroke (hemorrhage and cerebral hematoma), and unspecified stroke (cerebrovascular accident, cerebrovascular disorder, hemiplegia, and hemiparesis)

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Source: Barrett, et al JAMA Surgery, September 17, 2025 Researchers correlated insurance claims data and electronic medical records in a system that owns both an insurance plan (Highmark) and a provider system (Allegheny Health), and compared total medical expense for over 30,000 individuals who had either metabolic and bariatric surgery (sleeve gastrectomy) or were treated with GLP-1 medications between 2018 and 2023

Even more impressively, a pooled analysis showed that 25% to 46% of subjects with elevated baseline ALT achieved normalization by week 52, compared to only 18% of those receiving placebo