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Qian F, Mathias N, Moench P, Chi C, Desikan S, Hussain M, et al

Chronic GLP-1 receptor activation by Exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras G12D mouse model

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A polygenic integrative analysis has provided evidence that STAT function is significantly dysregulated in the ovary in PCOS (203)

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However, most CEAs of GLP-1RA versus insulin therapy for T2D patients have been model-based (e.g., Markov modeling simulation) analyses that used data mainly derived from clinical trials that assessed short-term drug efficacy in terms of biomarker changes among highly selective and homogenous patient populations [9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28]