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While you technically can restart, cycling on and off creates metabolic disruption and makes weight regain much more likely during off-periods

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According to the data presented by Eli Lilly from the SURMOUNT-5 study involving 700 patients, tirzepatide resulted in 47% greater weight loss after 18 months of treatment (25 kg vs 16.5 kg) alongside a reduced-calorie diet and increased physical activity compared to semaglutide