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Results vary and do not prove weight-loss effectiveness

The mechanistically correct prediction is that GLP-1s should look worse than dieting on DXA-measured lean mass precisely because they improve the metabolic conditions that inflate the lean compartment

The result is a system that struggles to absorb unprecedented demand without fragmenting the patient experience

Many patients report nausea, bloating, constipation, and in some cases sulfur burps when they start these medications or after dose changes

People at higher starting weights tend to lose more total weight

This can lead to irregular ovulation or anovulatory cycles, making it difficult to predict when a period is late