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Some people who have a colonoscopy without any sedation report little or no discomfort during the procedure

For patients with significant obesity or related conditions, that risk-benefit calculation tends to come out clearly in favor of treatment

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But profound, persistent weakness that worsens over weeks, particularly muscle-specific weakness that makes daily activities difficult, can indicate excessive lean tissue catabolism

While preclinical studies, primarily in animal models 17,18 , suggest a potential beneficial effect of GLP-1 RAs on mood and behavior, the clinical evidence in humans remains unclear 19,20