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doi: 10.1016/j.peptides.2022.170736

Large multicenter trials (including ERICCA and RIPHeart) showed no reduction in major adverse cardiac events with RPc 60

However, drug development timelines are inherently uncertain

Skip the loading phase Traditional creatine protocols often recommend a loading phase of 20 grams daily (split into 4 doses of 5 grams) for 5-7 days

1 This translates into a lower risk of hypoglycemia compared to other diabetes treatment options like sulfonylureas and insulin

2016;11(5) doi: 10.1371/journal.pone.0154727
