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in December 2017 ( [132] ), and subsequently an oral tablet form (Rybelsus) in 2019, and a high-dose injectable for obesity (Wegovy) in 2021

8 GIPR deficiency in mice leads to impaired glucose tolerance with reduced cell function, 9 while GIP overexpression results in improved glucose tolerance, enhanced cell function, and resistance to highfat dietinduced obesity

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Calculation of HOMA-IR index The homeostatic model assessment of insulin resistance (HOMA-IR) was calculated using the formula: HOMA-IR = [fasting insulin (mU/L) fasting glucose (mg/dL)/405] 75