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7 The following sections will discuss the overall approach to intensification of glucose-lowering agents, as illustrated in Figure 2 , with an emphasis on the role of GLP-1 RAs within the current recommendations

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First, Alzheimers disease and other dementias are strongly linked to metabolic dysfunctionespecially insulin resistance in the brain, sometimes labeled type 3 diabetes. Second, a class of diabetes and weight-management medicines called GLP-1 receptor agonists (GLP-1 RAs) shows early but increasingly consistent signals that they may lower dementia risk in people with type 2 diabetes, and possibly slow specific biological changes of Alzheimers in small clinical trials

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However, this is the first report of PETD associated with GLP-1 RAs