glp 1 agonists and sglt2 inhibitors combination Perspectives in weight control in diabetes – GLP-1–glucagon dual agonism Combination therapy with SGLT2 inhibitors

GLP-1 tells the pancreas, Hey, you need to put out insulin if thats needed, or it can give feedback to the liver to store extra glucose

Conclusion GLP-1 RAs provide clinically meaningful weight loss primarily through selective fat mass reduction, with relative preservation of lean tissue, supporting their role in achieving quality weight loss

& Edgar, P

That is quite odd as time after time with incretin therapy, usually by about 24 weeks the A1c reduction flattens out, but that is not at all what we see here

Summary Half a century has passed since the discovery of GLP-1, which has provided a new way for humans to fight diabetes

metformin may be considered