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The potential cardiovascular benefits of incretins have attracted much attention

The receptor is in an inactive conformation with compounds that restrict movement of the intracellular tip of helix VI, a movement that is generally associated with activation mechanisms in class A GPCRs
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Gimeno Orna JA, Ortez Toro JJ, Peteiro Miranda CM

doi: 10.1016/j.cmet.2017.11.003
