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These medications have been extensively studied and have demonstrated benefits in diabetes management, weight reduction, cardiovascular risk reduction, and improvement in overall metabolic health for appropriately selected patients

March 18 Product: Orchard Therapeutics Lenmeldy Indication: Metachromatic leukodystrophy Monday, the FDA gave a glimmer of hope to families of children with metachromatic leukodystrophy (MLD), a rare genetic disease affecting the brain and nervous system, with the approval of Orchard Therapeutics Lenmeldy

That said, the effect size of this circadian alignment is likely small compared to the overall impact of the drug itself

These medications are not suitable for everyone and may be contraindicated in patients with certain medical conditions including personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, severe gastrointestinal disease, or diabetic retinopathy

This is when 73% of discontinuations happen

Phase 3 (remaining TRIUMPH, TRANSCEND, SYNERGY trials): Results expected throughout 2026