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When compared to the IgG1 Fc domain, the IgG2 and IgG4 Fc domains may be more favorable in the development of GLP-1 RAs due to their lower affinity for Fc- and complement receptors [84, 85]

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Anyone with a personal or family history of medullary thyroid carcinoma or the condition known as multiple endocrine neoplasia type 2 falls into a group the trials specifically excluded