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The risk of generalised skin reactions, such as widespread rash or urticaria, appears to be low based on current evidence, though trial populations may not fully reflect the diversity of patients who would use the medication in routine clinical practice

(2014) 130:157988 10.1161/CIRCULATIONAHA.114.010389 [DOI] [PubMed] [Google Scholar] 67.Udell JA, Bhatt DL, Braunwald E, Cavender MA, Mosenzon O, Steg PG, et al

When the government delays granting a patent, the window of effective exclusivity is reducedprecisely the phase in which the company can explore the market without direct competition and recoup part of its investments

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