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The abdominal site typically shows the fastest and most consistent absorption due to blood supply and tissue characteristics, but thigh and arm injections are nearly identical in effectiveness

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For the semaglutide 1-mg-containing groups, semaglutide was initiated at 0.25 mg once weekly for the first 4 weeks, increased to 0.5 mg from weeks 5 to 8 and increased to 1.0 mg from weeks 9 to 71