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There was an increased risk of gastrointestinal disorders, hypotension, syncope, arthritic disorders, nephrolithiasis, interstitial nephritis and drug-induced pancreatitis.

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For emerging therapies with pronounced pharmacological effects, thoughtful study design is critical to ensuring reliable and interpretable data.

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James Januzzi, MD Although our primary endpoint fell short of statistical significance, there are encouraging signals in these results that increase enthusiasm to further evaluate effects of AT-001 on diabetic cardiomyopathy, saidJames Januzzi, MD, Hutter Family Professor of Medicine atHarvard Medical School, a cardiologist atMassachusetts General Hospital, director of Heart Failure Trials at theBaim Institute for Clinical Researchand the studys lead author

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