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Oats Oats contain a special soluble fibre called beta-glucan

reported that in hippocampal slices in seizure-induced SpragueDawley rats, exendin939, a GLP-1 receptor antagonist, significantly decreased GABA A Rbeta2/3 expression and increased GluR expression (ie, GluA14, GluN1, GluN2A, GluN2B).Reference Wen, Wu, Xie, Dan, Zhan and Shi 48 When samples were treated with GLP-1 RA, there was increased GABA A R2/3 expression and decreased GluR expression.Reference Wen, Wu, Xie, Dan, Zhan and Shi 48 Overall, the included studies support that GLP-1 RAs may be associated with increased glutamatergic receptor activity via multiple cellular and molecular mechanisms (Figure 2)

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The SURMOUNT-OSA study demonstrated that tirzepatide reduced the apnea hypopnea index (AHI), body weight, hypoxic burden, high-sensitivity C-reactive protein (hsCRP) concentration, and systolic blood pressure, and also improved sleep-related patient-reported outcomes in individuals with moderate-to-severe obstructive sleep apnea and obesity [145]

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