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Preclinical and initial human studies suggest that glucagon-like peptide-1 receptor agonists may be promising treatments for alcohol use disorder, but existing approved treatments should be used until safety and efficacy is demonstrated in clinical trials.

A brief review was conducted to explore current evidence on the interaction between GLP-1RAs and gut microbiotatermed the pharmaco-gut axis. Literature was examined to understand how specific microbial populations affect drug efficacy and insulin sensitivity